Rat Prefrontal Cortex Inactivations during Decision Making Are Explained by Bistable Attractor Dynamics
نویسندگان
چکیده
منابع مشابه
Perceptual decision making: Biases in post-error reaction times explained by attractor network dynamics
Perceptual decision making is the subject of many experimental and theoretical studies. Whereas most modeling analysis are based on statistical processes of accumulation of evidence, less attention is being devoted to the modeling with attractor network dynamics, even though they describe well psychophysical and neurophysiological data. In particular, very few works confront attractor models pr...
متن کاملRegional inactivations of primate ventral prefrontal cortex reveal two distinct mechanisms underlying negative bias in decision making.
Dysregulation of the orbitofrontal and ventrolateral prefrontal cortices is implicated in anxiety and mood disorders, but the specific contributions of each region are unknown, including how they gate the impact of threat on decision making. To address this, the effects of GABAergic inactivation of these regions were studied in marmoset monkeys performing an instrumental approach-avoidance deci...
متن کاملChanges in attractor dynamics predict altered perceptual decision making with dorsolateral prefrontal tDCS
The left dorsolateral prefrontal cortex (dlPFC) has been linked to the accumulation and comparison of perceptual evidence for decision making independent of sensory and response modalities. We investigated the possible neural dynamics underlying the role of dlPFC in perceptual decision making, through a combination of noninvasive neurostimulation in humans and computational modeling. First, we ...
متن کاملAmphetamine Exerts Dose-Dependent Changes in Prefrontal Cortex Attractor Dynamics during Working Memory.
Modulation of neural activity by monoamine neurotransmitters is thought to play an essential role in shaping computational neurodynamics in the neocortex, especially in prefrontal regions. Computational theories propose that monoamines may exert bidirectional (concentration-dependent) effects on cognition by altering prefrontal cortical attractor dynamics according to an inverted U-shaped funct...
متن کاملReversible inactivations of rat medial prefrontal cortex impair the ability to wait for a stimulus.
In simple reaction time tasks, lesions of rat dorsomedial prefrontal cortex impair the ability to wait for trigger stimuli and result in increased premature responding. This effect could be due to impairments in attending to trigger stimuli, estimating the timing of trigger stimuli, or inhibitory control of the motor response. Here, we examined these issues by reversibly inactivating dorsomedia...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neural Computation
سال: 2017
ISSN: 0899-7667,1530-888X
DOI: 10.1162/neco_a_01005